Ketamine for Chronic Pain
Ketamine has emerged as a promising option for managing chronic pain, particularly in conditions such as neuropathic pain and Complex Regional Pain Syndrome (CRPS). Its unique mechanisms of action address multiple pathways involved in the persistence of pain, offering relief when other treatments may have fallen short.
Complex Regional Pain Syndrome (CPRS)
Chronic Pain Syndrome (CPS)
Chronic Neuropathic Pain
Phantom Limb Pain
Fibromyalgia
Chronic Fatigue Syndrome
Migraines
Endometriosis/PMDD
Cancer Pain
and others...
NMDA Receptor Blockade
In neuropathic pain, overactivation of NMDA receptors increases nerve sensitivity and amplifies pain signals. Ketamine blocks these receptors, interrupting this cycle and reducing pain.
Boosting BDNF
Chronic pain reduces BDNF and synaptogenesis, impairing brain repair. Ketamine boosts BDNF, enhancing neuroplasticity and neurogenesis to support recovery and reduce pain.
Engaging Mu Opioid Receptors
Ketamine interacts with mu opioid receptors which may enhance pain relief and complement its other mechanisms.
Immune System Modulation
Chronic pain involves inflammation with elevated Interleukin-6 (IL-6) and Tumor necrosis factor (TNF). Ketamine reduces these cytokines and nitric oxide along with converting toxic quinolinic acid to Kynurenic acid to reduce inflammation and providing neuroprotection.
Targeting Brain Regions
CRPS and other chronic pain conditions are believed to affect the prefrontal cortex, a region involved in pain perception and emotional regulation. Ketamine has been shown to act on the medial frontal cortex and the hippocampus, helping to restore balance and improve the brain’s ability to process and cope with pain.
Pain and Mood Connection
Depression and chronic pain tend to overlap, as they share common brain pathways that amplify both emotional distress and pain perception. Ketamine helps by blocking NMDA receptors can help reset neural connections associated with mood and pain regulation. This dual-action approach has the potential to provide relief for both depression and chronic pain, improving overall quality of life for patients.
Ketamine Infusions for Pain
IV/IM Ketamine Pain Session
$1000
4 hour infusion, 5-6 hour appointment
(additional cost if extends past 6 hours)
Non-Neuropathic Chronic Pain
Loading Series: 4 consecutive infusions
Maintenance infusions: varies
Neuropathic Chronic Pain
Loading Series: 5 consecutive infusions
Maintenance infusions: varies